Berry Shirayuki is introduced in Tokyo Mew Mew a la Mode as the series' main protagonist, as, the Mew Mews' leader, Ichigo, has gone to study abroad in England. The twelve year old girl becomes the sixth Mew Mew and temporarily takes Ichigo's place by becoming the new leader of the group.
Berry is the first Mew Mew to be infused with the DNA of two endangered species, the Andean Mountain Cat and the Amami Rabbit, after she follows Ryou Shirogane to the Cafe Mew Mew to thank him for saving her from a bad fall, accidentally enters the Mew Mew's headquarters, and runs through an experimental new machine for infusing DNA into girls.